Viral Teamwork Pushes CRISPR to the Breaking Point
نویسندگان
چکیده
منابع مشابه
Breaking the silence on viral hepatitis.
Until recently, the silent epidemic of viral hepatitis has eluded a unified national public health strategy for controlling morbidity and mortality. Consequently, untreated chronic viral hepatitis affects between 3.5 and 5.3 million Americans and continues to fuel rising incidences of progressive liver disease, liver failure, and liver cancer (1). Chronic hepatitis C virus (HCV) infection affec...
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Following the formation of every peptide bond during protein synthesis, the tRNA:mRNA complex must be translocated by precisely three nucleotides through the densely packed interior of the ribosome. While recent crystal structures have revealed a detailed molecular view of an RNA-only active site for peptide bond formation, far less is known about how two 25 kDa tRNA substrates are coordinately...
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ژورنال
عنوان ژورنال: Cell
سال: 2018
ISSN: 0092-8674
DOI: 10.1016/j.cell.2018.07.025